Oligosaccharide substrate preferences of human extracellular sulfatase Sulf2 using liquid chromatography-mass spectrometry based glycomics approaches.
Sulfs are extracellular endosulfatases that selectively remove the 6-O-sulfate groups from cell surface heparan sulfate (HS) chain.By altering the sulfation at these particular sites, Sulfs function to remodel HS chains.As a result of the remodeling activity, HSulf2 regulates a multitude of cell-signaling events that depend on interactions between